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By PEOPLE.COM/Jen Juneau
Oct 14, 2016 @ 8:45 am
Tiffany Rose/Getty

David Arquette has something exciting to Scream about: a new baby on the way!

On Wednesday, the actor took to Instagram to share a video of his 2-year-oldson Charlie West holding an ultrasound photo to announce he and wife Christina are expecting their second child together.

“So incredibly blessed and honored that my wife @christinaarquette is pregnant with a baby boy!” the former In Case of Emergency star captioned the clip.

“Thank you Christina and humbled gratitude to G-D for this tremendous gift!” adds Arquette, 45. “Charlie and Coco are so excited and I am over the moon!!!”

“Say, ‘Hi, brother!’ ” Christina says from behind the camera in the video, which shows Charlie kissing and snuggling the ultrasound photo.

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“Baby?” he says.

“Yeah, it’s a baby in my belly,” his mom replies.

“Hi, baby!” he says before following up with, “Hi, brother!” and planting a sweet smooch on the photo.

The best thing in life #love #family

A photo posted by David Arquette (@davidarquette) on

Aside from Charlie, Arquette is also dad to 12-year-old daughter Coco from his previous marriage to Courteney Cox.

And it’s likely the actor is ready to have a newborn around again.

“Since Charlie has come into my life, I love Coco more than ever,” he told People in 2014 when his son was an infant. “Having a son has brought back memories and made me realize how much I miss enjoying her as a baby.”

The baby news comes a month after Arquette’s sister Alexis Arquette passed away from complications related to AIDS.