Watch George Clooney's Shocked Reaction Upon Hearing About Angelina Jolie and Brad Pitt's Divorce
In fact, Clooney, 55, heard news of the split through the media. At Tuesday's Leaders Summit for Refugees at the United Nations General Assembly in New York, the actor was asked by a CNN reporter to comment on Jolie and Pitt's breakup.
"What happened?" Clooney said, clearly taken aback. "I didn't know that. I feel very sorry then. That's a sad story and unfortunate for a family. It's an unfortunate story about a family. I feel very sorry to hear that."
Adding, "This is the first I've heard of it."
Clooney and Pitt, 52, share a friendship that spans over a decade. They've shared the big screen in the Ocean's trilogy from 2001 to 2007 and then costarred in 2008's Burn After Reading.
Jolie, 41, filed divorce papers on Monday, noting in court documents that she and Pitt have been separated since Sept. 15. Jolie cited irreconcilable differences for their split, and did not request child or spousal support for their six kids.
RELATED VIDEO: Brad Pitt & Angelina Jolie Release Separate Statements About Their Divorce
"I am very saddened by this, but what matters most now is the well-being of our kids," Pitt said in the statement to People. "I kindly ask the press to give them the space they deserve during this challenging time."
The couple famously met on the set for their 2005 thriller Mr. & Mrs. Smith. They were married in 2014—two years after getting engaged.
Meanwhile on Tuesday, Clooney and his wife Amal were spotted walking hand in hand after their UN session.
The couple, who will be celebrating their two-year wedding anniversary later this month, were also seen showing affections for one another by holding hands during the meeting in which they pledged to do more for the international refugee crisis.