The 12 Best Clinical Strength Deodorants of 2022, Tested and Reviewed

Uriage Clinical Strength Deodorant was the clear winner.

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Clinical Strength Deodorant

InStyle / Jhett Thompson

If you’ve ever raised your hand to hail a cab or leaned in for an around-the-neck hug only to catch a whiff of something not so pleasant, chances are you’ve looked into adding a clinical strength deodorant to your self-care routine. The problem is, with so many options on the market, it can be difficult to know which actually perform for hours on end, let alone throughout an entire day’s worth of wear.

With this in mind, we set out to uncover the best clinical strength deodorants of 2022. We started by sussing out the top-rated deodorants on the market. Rather than relying solely on consumer reviews, though, we then had a group of reviewers put 34 deodorants to the test in our lab. To deeply analyze their performance, each reviewer wore their selected deodorants for 24 hours straight, taking note of its texture, scent, efficacy, transfer resistance, and overall wear in the process. At the close of testing, we found that Uriage Clinical Strength Deodorant held up the best throughout everyday activities, as well as brisk walks, low-intensity workouts, and seemingly endless jumping jacks. But that’s just one of a dozen.

Keep reading for the 12 best clinical strength deodorants of 2022.

Best Overall: Uriage Clinical Strength Deodorant

Uriage Clinical Strength Deodorant


What We Love: It smells fresh and effectively blocks odor.

What We Don’t Love: It doesn’t fully block sweat all day long.

Designed to last for 24 hours, Uriage Clinical Strength Deodorant has made waves for its fresh, long-lasting appeal. It doubles as an antiperspirant, meaning it blocks odor, as well as sweat. While our tester admittedly found that it doesn’t last in its full glory for 24 hours, they were amazed by the product's performance nonetheless. “The deodorant went on smoothly and was instantly absorbed — it wasn’t tacky, sticky, or greasy, and left no stains on the black shirt that I wore,” they say. “I used it as directed, and even though I had minor sweat, no odor permeated through my clothes, and it still smelled and felt good."

Other highlights of this top-rated deo? It’s hypoallergenic, has a fresh unisex scent, and it’s infused with Uriage Thermal Water to nourish under-arm skin — all for under $15.

Price at time of publish: $12

Type: Roll-on | Scent: Fresh | Lasting power: ~24 hours | Antiperspirant: Yes

Best Budget: Certain Dri Clinical Prescription Strength Antiperspirant

certain dri antiperspirant
courtesy of Amazon.

What We Love: It neutralizes odor without covering it up with a fragrant scent.

What We Don’t Love: It feels quite wet upon application.

Considering the name of this deodorant, you might be surprised to find that it applies wet — our tester was. That said, once on, Certain Dri Clinical Prescription Strength Antiperspirant dries down to a matte finish that offers full coverage against odor and sweat, without leaving any residue on clothes in the process.

“The deodorant neutralized any odor, but didn't have any noticeable fragrance either,” our tester reveals. “I felt coverage spanned over 24 hours — odor only started creeping in just after 24 hours, and [my full-fledged] natural body odor [only became noticeable] after a rigorous day of work the second day.”

While the deo performs well, feels comfortable, and doesn’t transfer, our tester admits that it has a slightly chalky feel, which they imagine would become more noticeable with more than two swipes of the product. Still, given the performance and the price, they found it was impossible to beat.

Price at time of publish: $6

Type: Roll-on | Scent: Unscented | Lasting power: 24+ hours | Antiperspirant: Yes

Best Splurge: Donna Karan Cashmere Mist Deodorant

Cashmere Mist Deodorant Stick by Donna Karan
Courtesy of Amazon.

What We Love: It has the most dainty, fresh scent that mimics a luxury perfume.

What We Don’t Love: It doesn’t fully block sweat and leaves a noticeable white residue.

Donna Karan Cashmere Mist Deodorant is beloved by over 35,000 Sephora shoppers — and for good reason. Unlike most deodorants, this deo is designed to smell like a luxury perfume. “This scent is very unique; it’s definitely the best-smelling deodorant I've ever experienced,” our tester reveals.

Scent aside, we found the deodorant, which is an antiperspirant stick, performs well, too. “The consistency of the product is very light, almost powdery,” our tester says, marveling over just how smoothly it applies. While it doesn’t block against odor and sweat all day long, it does adequately provide coverage for 12 to 16 hours. The one downside is that it leaves a slight-but-noticeable white residue. “There was a tiny, tiny amount of white on my t-shirt, but not much to bother me,” our tester admits.

Price at time of publish: $38

Type: Stick | Scent: Cashmere | Lasting power: 12 hours | Antiperspirant: Yes

Best Antiperspirant: Secret Antiperspirant Deodorant with Pure Essential Oils

Secret Essential Oils Invisible Solid Antiperspirant and Deodorant


What We Love: It works well to prevent sweat and effectively blocks odor for up to 24 hours.

What We Don’t Love: The consistency of the deodorant is slightly dry, so it doesn’t apply very smoothly.

Secret Antiperspirant Deodorant for Women With Pure Essential Oils smells deliciously of coconut and mandarin — which our tester found to be one of three key highlights of the product. “The scent was really lovely; it smelled fresh and clean, without being too perfumey or overpowering,” they say. “If they made a candle version of it, I would burn it in my room all day long.”

Another key takeaway? It’s an incredible antiperspirant — in fact, the best of the bunch. “After completing a 15-minute brisk walk on the treadmill, I had worked up a sweat on my forehead and neck, but didn't feel much, if any, dampness on my armpits — this deodorant is very effective,” our tester says. “Over the course of 24 hours, my armpit would get slightly damp when I was active (walking outside in the heat, packing for my move, etc.), but not enough to make my shirt sleeve wet. The antiperspirant effects are impressive.”

From a transfer stance, this deo wowed us even further. “Because of the standard dry, white form of deodorant, I expected there to be a significant white mark on the inside of my t-shirt, but I had to really look to find one minor white dot,” our tester says. “I was pleasantly surprised by the lack of transfer.”

The only downside was the consistency. “It didn’t glide smoothly onto my armpits, as it was slightly dry,” our tester says. “But it wasn't sticky or greasy — it had a barely-there feeling, which I found comfortable [once applied].”

Price at time of publish: $8

Type: Stick | Scent: Coconut Oil + Mandarin | Lasting power: 24 hours | Antiperspirant: Yes

Best for Sensitive Skin: Vanicream Antiperspirant Deodorant

Vanicream Antiperspirant Deodorant

Courtesy of Amazon

What We Love: It doesn’t have a scent but it totally blocks the smell of everyday underarm odor.

What We Don’t Love: It leaves a white residue behind.

If you have sensitive skin, this fragrance-free antiperspirant deodorant is a must. Beloved by over 10,000 Amazon shoppers, Vanicream Anti-Perspirant Deodorant works well to block everyday sweat and odor — as in the type you’d experience going about your commute, running errands, engaging in a low-to-moderate intensity workout, and so on. “In 24 hours, I did a brisk walking workout, had a very hot and sweaty commute home, and did a second low-intensity strength training workout — I'm pretty impressed that there is no odor,” our tester reveals.

While it works well to block sweat and provide odor protection, this stick deodorant does leave behind white residue. “This product doesn't claim to go on clear. It did leave some white residue on my shirt after a workout, but it washes out easily and doesn't result in any staining,” our reviewer says.

That’s not enough to be a deterrent, though. “I really love that this deodorant doesn't have any fragrance at all. And since I went the full 24-hour period (with a few workouts and a very sweaty commute) without noticing any smells, I'd say it doesn't need any added fragrance to work.”

Price at time of publish: $32 for a three-pack

Type: Stick | Scent: Unscented | Lasting power: 24 hours | Antiperspirant: Yes

Best Unscented: DERMAdoctor Total Nonscents Ultra Gentle Antiperspirant

DERMAdoctor Total Nonscents Ultra Gentle Antiperspirant


What We Love: It’s totally unscented but it fully blocks all natural body odor.

What We Don’t Love: The ball applicator is on the smaller side, so it requires more passes for total coverage.

DERMAdoctor Total Nonscents Ultra Gentle Antiperspirant is another fabulous option for sensitive skin, not to mention our top pick as far as unscented formulas go. “I have very sensitive skin so most times scented products irritate my skin or don’t work well with my body chemistry,” our tester shares. “As such, this deodorant was perfect for my needs. I couldn’t smell any body odor under my arms after 24 hours, even with it being unscented.”

In addition to blocking odor — even after a rigorous jumping jack warm-up and stint on the treadmill — our tester found that this deodorant, which goes on clear, works exceptionally well to minimize sweat. “I didn’t perspire as much while using this deodorant, which was nice. It's rare that roll-on deodorants with ball applicators work that well with my body, but I didn’t smell or feel sweaty at all.”

Price at time of publish: $24

Type: Roll-on | Scent: Unscented | Lasting power: 24 hours | Antiperspirant: Yes

Best Solid: Secret Clinical Strength Invisible Solid Antiperspirant and Deodorant

Secret Clinical Strength


What We Love: It provides optimal odor protection for over 24 hours.

What We Don’t Love: The deodorant can sometimes crack and crumble.

The Secret Clinical Strength Invisible Solid is your typical smooth white stick deodorant with far-beyond-typical odor-blocking benefits. After 24 hours of wear, our tester found that their armpits still smelled lightly fragranced with no trace of body odor. “My armpits were a little damp after a brisk 15-minute walk but [it didn’t show], and the odor was controlled very well,” they share. “This is officially my all-time favorite deodorant — it has, by far, excelled my expectations.” As with all solids, if you drop it, it can crack and crumble, so be gentle with it when you’re tossing it in your gym bag or suitcase.

Price at time of publish: $13

Type: Stick | Scent: Lavender | Lasting power: 48 hours | Antiperspirant: Yes

Best Gel: Secret Derma+ Invisible Gel Antiperspirant and Deodorant

Secret Derma+ Invisible Gel Antiperspirant and Deodorant,


What We Love: It smells great and comes in multi-packs.

What We Don’t Love: It doesn’t last a full 24 hours.

Prefer the texture of gel deodorants? Secret Derma+ Invisible Gel Antiperspirant and Deodorant has earned five-star accolades from over 1,800 Amazon shoppers. During our testing, we found that it applies quite wet but it dries down after a few seconds or so. “There’s no transfer at all and it smells very nice,” our reviewer says. That said, it doesn’t last for the full 24 hours it promises. “The fragrance wore off by the end of the day and you can definitely smell the sweat,” our testers says. “Still, I love how effective and affordable this deodorant is [for shorter wear] — I would recommend this product to someone who does not sweat very much.”

Price at time of publish: $7

Type: Gel Tube | Scent: Coconut | Lasting power: 12+ hours | Antiperspirant: Yes

Best Cream: Biotherm Deo Pure Antiperspirant, Cream

 Biotherm Deo Pure Antiperspirant, Cream


What We Love: It doesn’t leave any transfer even though it’s a white cream.

What We Don’t Love: The applicator is a squeeze tube, which is a bit different.

For a less wet, more creamy deodorant application that dries down for matte wear, check out Biotherm Antiperspirant Cream. “The deodorant went on really nicely — with the unusual dispenser, I felt like I could rub in a smaller amount without adding more to my armpit, so it fully absorbed without getting caked on,” our tester shares.

In addition to applying beautifully, this antiperspirant smells subtle and delightful. “I didn't realize this deodorant was scented until I really put my nose into my armpit — even then, I rechecked the packaging to make sure it wasn't just leftover body wash or fabric softener scent,” our tester says.

Best of all, despite being a white cream that takes a second to dry down, it doesn’t transfer at all. “I wore a dark blue shirt to the test and I didn't see any transfer — the fact that it was so easy to rub in may have helped,” our tester says.

Price at time of publish: $22 (originally $28)

Type: Cream Tube | Scent: Floral | Lasting power: 24 hours | Antiperspirant: Yes

Best Wipes: SweatBlock Antiperspirant

SweatBlock Clinical Strength Antiperspirant Wipes

What We Love: The wipe format makes them especially convenient for travel and on-the-go use.

What We Don’t Love: They make for a musty end smell — but not until 24 hours after application.

Whether you travel a lot, are looking for a deodorant solution in your car or gym bag, or simply prefer the idea of a wipe over a stick, gel, or cream, SweatBlock Clinical Strength DRIBOOST Antiperspirant Wipes are worth considering. Despite being unscented, the expertly-formulated wipes prevent BO for hours on end (though, our tester did notice a musty smell around the 24-hour mark). “I stayed dry throughout my entire wear,” our tester adds. “The product appears to be a sweat reducer (the brand claims for up to seven days), and I think combined with a stick deo after day-one it would be a great pick for super sweaters.”

Price at time of publish: $20

Type: Wipe | Scent: Unscented | Lasting power: Seven days | Antiperspirant: Yes

Best Pack: Degree Advanced Antiperspirant Deodorant

Degree Advanced Antiperspirant Deodorant


What We Love: It’s sold in sets of four, so you can always have a deodorant on hand.

What We Don’t Love: The scent is quite strong, so it offends some.

When you find a deodorant you love, it’s only natural to want to keep a backstock. With Degree Advanced Antiperspirant Deodorant, you can do so by picking up one of the best-selling bundles of four, which have earned five-star reviews from over 8,000 Amazon shoppers. “After a full day of testing, commuting, sleeping, etc., I'm so impressed by the results,” our tester marvels. “Not only am I stink-free but my underarms also stayed dry the entire time, too. This would be an especially great product for hard workouts or marathon days.”

Price at time of publish: $16

Type: Stick | Scent: Shower Clean | Lasting power: 72 hours | Antiperspirant: Yes

Best for Workouts: Arm & Hammer Ultra Max

Arm & Hammer Ultra Max


What We Love: It smells like fresh laundry detergent and works well to prevent sweat and BO.

What We Don’t Love: The applicator is quite wide, which makes applying it a bit unwieldy.

Arm & Hammer Ultra Max Deodorant is formulated with baking soda to naturally absorb odor and help prevent excess sweating — which is especially important when you’re powering through an intense workout. “This deodorant has a smooth application, great smell, and it’s an amazing bang for your buck,” our tester confirms. “I didn’t feel sweaty at all during wear, and the scent smells like laundry detergent, which I’m personally obsessed with.”

The only downside is the size of the applicator. The mouth of the stick is quite wide, which we assume is to encourage only passing it over the pit area once or twice, as the directions say to only use thin layers.

Price at time of publish: $5 (originally $7)

Type: Stick | Scent: Cool Blast | Lasting power: 24 hours | Antiperspirant: Yes

Our Testing Process

On the hunt for the best clinical strength deodorants of 2022, we started by rounding up the 34 most highly-rated products on the market. Then, the InStyle team of testers put every deodorant to the test, evaluating each based on its texture, efficacy, scent notes, transfer resistance, and overall wear. They did so by wearing each deodorant for at least 24 hours and taking note of how they held up in typically stinky and/or sweaty situations — like working out, commuting, and sleeping. In doing so, they were able to weed out the less effective formulas to deliver the 12 best clinical strength deodorants of 2022.

What to Keep in Mind


When shopping for clinical strength deodorant, it’s important to keep the format in mind. For starters, do you prefer stick, gel, cream, roll-on, or wipe formulas? Once you narrow that down, you’ll be better able to find the best option for your preferences. What’s more, consider whether you’re in the market for a highly effective deodorant or an antiperspirant (which is typically what people are referencing when discussing clinical strength deodorants). Depending on your answer, you’ll be able to further whittle down your product pool.


Some deodorant scents can be quite overpowering, while others hardly last. Then there’s the fact that some people simply can’t tolerate fragrance on their skin. As such, take note of how you want your pits to smell, and whether or not they can withstand the scent. If you prefer fragrance, Donna Karan Cashmere Mist Deodorant features a perfume-esque cashmere scent that our testers say is extremely unique. For those who prefer unscented formulas, though, try DERMAdoctor Total Nonscents Ultra Gentle Antiperspirant.

Lasting Power

Are you looking for a deodorant that will last throughout a day at the office? Or perhaps you’re hoping for something that will get you through your morning workout, work, and after-work drinks. You’ll want to pick a deodorant with compatible hourly protection based on your preference. Our best overall pick Uriage Clinical Strength Deodorant provides an impressive 24 hours of protection, so you can feel fresh and clean for an extended period of time.

Your Questions, Answered

How is clinical strength deodorant different from regular deodorant? 

Clinical strength deodorant is the common term for antiperspirant. “Clinical strength is a term used by companies to indicate that the product has a higher amount of aluminum (the active ingredient in antiperspirants) than the regular strength,” says Jeremy Fenton, M.D., a board-certified dermatologist at Schweiger Dermatology Group in New York City and Long Beach, NY. “This is usually around 20 percent concentration.” While a higher percentage of aluminum can mean less sweating and odor, Dr. Fenton points out that the higher concentration can also potentially lead to a higher chance of irritation. As such, if you have sensitive skin, you’ll want to be especially mindful about which clinical strength deodorant you reach for, ideally opting for a fragrance free product. (Vanicream Anti-Perspirant Deodorant is our top pick for sensitive skin.)

Diving deeper into the logistics, board-certified dermatologist DiAnne Davis, M.D., says that deodorants are primarily intended to chemically block BO-causing bacteria. “They do not affect wetness or dampness from sweating,” she explains.

Antiperspirants, on the other hand, contain active ingredients (like aluminum) to physically block sweat ducts and prevent moisture. “They create superficial plugs just below the surface of the skin to block the sweat ducts,” Dr. Davis explains.

How does clinical strength deodorant work?

It works the same as regular antiperspirant. “Clinical strength items contain a higher concentration of aluminum salts which are substances that are absorbed into the sweat gland, and form a plug that slows down the rate of perspiration that comes from the sweat gland,” Dr. Davis explains. This is notably different from deodorants, which simply chemically block odor.

Can you use regular deodorant and clinical strength deodorant together?

You can, but that doesn’t mean you need to or should. “If you are using clinical strength, applying a weaker version of the same thing in addition would be of no value,” Dr. Fenton says. That said, if you peruse the deodorant aisle, you’ll likely find that most products are a combination of deodorant and antiperspirant to adequately block BO and prevent excessive sweating.

Does clinical strength deodorant cause cancer?

While clinical strength deodorant gets a bad rap for potentially causing cancer thanks to its aluminum make-up, Dr. Davis points out that there’s no definitive evidence. “According to the National Cancer Institute, to date there has been no scientific evidence that links the use of antiperspirants or deodorants to the development of breast cancer,” she assures us.

Does clinical strength deodorant have aluminum?

Point blank: Yes. All antiperspirants, and two-in-one antiperspirant-deodorants, contain aluminum, as it’s the ingredient that blocks sweat glands.

What Is InStyle Picks?

Did you notice the InStyle Picks seal of approval at the top of this story? That means our team of testers has reviewed every product on this list using a unique methodology to ensure it's really worth your time, money, and attention. We may get samples for free to try but we never promise positive (or any!) coverage in exchange. Put simply: InStyle Picks are products we love, and we've put them to the test to be sure you will too.

Why Shop With Us

Rebecca Norris has covered beauty for over eight years. For this story, she spoke with a group of a dozen testers, as well as two board-certified dermatologists, to determine the best clinical strength deodorants of 2022, as well as what to look for in a high-quality formula.

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