Beauty Skincare 4 Under-the-Radar Acne-Fighting Ingredients That Aren't Benzoyl Peroxide Bye-bye stubborn acne. By Erin Lukas Erin Lukas Instagram Twitter Erin is a Brooklyn-based beauty editor and has been with InStyle since 2016. She covers all facets of beauty for the site. InStyle's editorial guidelines Updated on January 19, 2023 @ 09:39AM Pin Share Tweet Email In This Article View All In This Article Succinic Acid Sulfur Zinc Comedoclastin Photo: Susana Ram/Stocksy/Adobe Stock If you're one of the 50 million people in America who gets acne, you're probably well acquainted with salicylic acid and benzoyl peroxide. These two chemical exfoliants are often recommended by dermatologists because they are scientifically proven to kill acne-causing bacteria beneath the skin. However, they don't always work for everyone. For some, the popular acne-fighting ingredients may be too harsh or conflict with other skincare products applied (such as those containing retinol). So how about considering alternative acne treatments? The 15 Best Acne Treatments for Every Type of Spot Ahead, learn more about four under-the-radar ingredients used to treat breakouts, according to top dermatologists. Succinic Acid This buzzy ingredient is derived from amber or sugar cane through a fermentation process. It helps control excess sebum and shine, which can potentially lead to breakouts. However, Dr. Jeanine Downie, board-certified dermatologist and founder of Image Dermatology, says while succinic acid can decrease oil levels, it can be drying and isn't as potent as salicylic acid. With that in mind, succinic acid can give a product a boost when formulated in conjunction with salicylic acid and other ingredients tailored to acne-prone skin. The Inkey List Succinic Acid Acne Treatment Courtesy In addition to succinic acid, this spot treatment contains salicylic acid and sulfur (more on that ingredient in a sec) to treat blemishes and blackheads. Hyaluronic acid provides a bit of hydration to prevent dryness and flaking, so the treatment can be worn underneath makeup during the day. It's also gentle enough for sensitive skin. As someone with sensitive skin, I found this treatment to be calming for the inflamed zit I had near the corner of my mouth without being overly drying. To shop: $10; theinkeylist.com I've Finally Found a Skincare Routine That Gives Me a Plump, Breakout-Free Complexion Perricone MD Acne Relief Calming Treatment & Hydrator Courtesy This lightweight serum can be used twice a day to help minimize inflammation, acne-exacerbating bacteria, and dryness. Along with succinic acid, niacinamide, lactic acid, squalane, and citrulline (a calming alpha-amino acid) are the hero ingredients of the treatment. To shop: $45; amazon.com Why Squalane and Hyaluronic Acid Are a Match Made in Anti-Aging Skincare Heaven Sulfur "Topical sulfur can be an effective treatment for acne," says Dr. Downie. "It is effective for some people because it is antibacterial." This means sulfur can reduce inflammation and bacteria growth that leads to breakouts. While sulfur is safe for all skin types, Dr. Downie points out people with allergies to the ingredient should avoid using it as an acne treatment. Sensitive skin types may find sulfur too drying and irritating, especially when combined with benzoyl peroxide. Kate Somerville EradiKate Acne Treatment Courtesy Kate Somerville's spot treatment contains the highest level of sulfur allowed in a topical product. Exfoliating BHA acid and zinc oxide (we'll also get into this ingredient later) round out the formula. Throughout the years, I've returned to this cult-favorite pink goop because I see a significant improvement in the size and redness of my zits overnight. To shop: $28; sephora.com Here's What You Can Do to Reduce Pimples Overnight Dr. Dennis Gross DRx Blemish Solutions Clarifying Mask Courtesy For an allover treatment, try a face mask infused with sulfur and other acne-fighting ingredients. Dr. Dennis Gross' overnight mask absorbs excess oil, bacteria, and impurities as you catch some z's. Alternatively, you can use the mask as a spot treatment. To shop: $29; sephora.com The 13 Best Face Masks for Acne of 2023 Zinc While zinc is an essential nutrient your body needs to support immunity, it also can be an effective acne treatment that reduces inflammation and excess oil production. "The exact mechanism of action of how zinc works in acne treatment is poorly understood but is thought to be associated with inflammatory pathways," says Dr. Shari Sperling, board-certified dermatologist and founder of Sperling Dermatology. In addition to acne treatments, zinc is also found in physical sunscreens (zinc oxide) and anti-dandruff shampoo (zinc pyrithione). If you want to incorporate zinc into your skincare routine, just proceed with caution because it can cause some sensitivity. To avoid any serious issues, Dr. Sperling recommends doing a patch test first. "You could have a topical reaction to zinc, so make sure you test an area of your skin prior to using to see if you are sensitive to it," she says. Should Zinc Be in Your Skincare Routine? Zinc can also be taken orally to treat acne. "Zinc is over the counter as zinc acetate, zinc gluconate, and zinc sulfate, and has different formulations, Dr. Sperling explains. "Zinc is also found in food such as beans and dairy products. You should always check with your physician to make sure you are taking the appropriate amount of zinc." Dr. Sperling says zinc sulfate has been shown to be more effective with severe acne, but has been associated with side effects such as nausea, vomiting, and diarrhea, so keep that in mind when considering zinc supplements as a treatment option. Glossier Super Pure Niacinamide + Zinc Serum Courtesy Glossier created its Super Pure serum for skin that tends to get dried out or irritated from the typical acne treatments. It combines zinc PCA to decongest pores and 5% niacinamide to help balance oil levels and has a water-gel texture that absorbs into skin without any greasy residue. To shop: $29; glossier.com Niacin vs. Niacinamide — Which Is Better For Your Skin? Pai All Becomes Clear Blemish Serum Credo Beauty This concentrated serum works to minimize congestion in oily, acne-prone skin while simultaneously supporting the skin barrier to prevent irritation and flakiness. Pai has formulated it to be gentle enough to use every day on weeks when you're experiencing more acne, but using it once or twice a week will help maintain clear skin, too. To shop: $69; credobeauty.com Comedoclastin If you haven't heard of comedoclastin yet, it's because the ingredient is exclusive to Avène, a brand known for gentle, healing products formulated with its signature thermal spring water. Comedoclastin comes from milk thistle and has been discovered to have pimple and oil-reducing properties. "It's a great ingredient because it does play nice with other active ingredients and does not cause any irritation or concern when using with other products," says Dr. Mona Gohara, board-certified dermatologist and associate clinical professor of dermatology at the Yale School of Medicine. The brand's clinical studies show that comedoclastin can improve the appearance of acne in just a week. "Significant changes can be seen in clearing acne spots from just seven days of use," Dr. Gohara shares. "It visibly reduces blemishes up to 22% from seven days and up to 39% in two months when observed under dermatological control." I Test Skincare for a Living, and This Acne-Curing Oil Has Been My Staple for Almost 2 Years Avène Cleanance Concentrate Blemish Control Serum Courtesy Avène's serum can be used on all types of acne at every stage, including hormonal cysts, and is also soothing, thanks to the addition of the brand's thermal spring water. Because the serum has a water-gel texture, a little goes a long way. I've been using it every night for over a month and still haven't hit the bottom. The fact that the comedoclastin plays nice with all other ingredients makes it a no-brainer to try. I don't have to think about alternating my other actives like retinol to treat my hormonal breakouts. To shop: $28; dermstore.com Sources InStyle uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Skin Conditions by the Numbers. American Academy of Dermatology.