Relive the 9 Best Moments from the 2016 MTV Movie Awards

Theron took home the trophy for Best Female Performance for Mad Max: Fury Road. "The story of Fury Road is in part a story of the power of women and the power to create our own destinies. So tonight I accept this award on behalf of my own little Furiosa, my daughter, August Simone, and on behalf of all of the Furiosas out there. You are the true warriors."

"I thought that was like code for the old ass dude award," Smith joked upon accepting the trophy. All kidding aside, the Concussion star was honored to accept the award. "I'm humbled and I just want all of you to know that I'm dedicated to being a light in this world."

The leading lady of The Boss was the first woman to take home the Comedic Genius Award. McCarthy thanked the many female comediennes who inspired her, as well as her mom, who taught her not to fear being the butt of the joke, to forget about being likable, and to "lovingly go for the kill."

Rogen stepped on stage looking more muscular than usual, an obvious jab at the incredible shape that Efron has gotten into for his new movie, Baywatch. "I'm so hungry. This award is as close as I'll get to eating popcorn ever again," Rogen complained.

Will Smith, Cara Delevingne, Margot Robbie, and Jared Leto took the stage to premiere new footage from their film, Suicide Squad, and the crowd went wild. Fans almost toppled the barricades holding them back when the cast came on stage, the Los Angeles Times reports.

Ariana Grande took to the stage to perform her new single, "Dangerous Woman," looking like a young Mariah Carey. But before she gave her incredible performance, Kendall Jenner and Gigi Hadid, the supermodel duo dubbed "KenGi," introduced Grande rocking some sexy lace-up shoes and a new set of bangs.

Wilson and Devine took home the award for Best Kiss for their epic lip lock in Pitch Perfect 2. After joking that they have "no sexual chemistry" in real life, the duo went at it on stage!

After the set transformed into 1920s New York City, the star of the new J.K. Rowling movie, Fantastic Beasts and Where to Find Them, popped out of a suitcase and onto the stage. Redmayne "had the most astounding time getting to leap back into the world of J.K. Rowling's imagination," he said, introducing the world premiere of the film's trailer. "I'm excited to show you tonight just a wee glimpse of what's in store next November."

The True Blood star said he was planning on presenting shirtless, but was told that Zac Efron already did that two years ago. "It was a historic moment," Samuel L. Jackson told him. Instead, he decided to go the more "classy and sophisticated" route and climb on stage sans pants.