Evelyn Lauder—a cosmetics executive and breast cancer activist—passed away on Saturday at the age of 75 from complications of non-genetic ovarian cancer. During her career at Estée Lauder, Mrs. Lauder helped oversee some of the brand’s biggest successes including Clinique and the best-selling fragrances Pleasures and Beautiful. In 1993, four years after being diagnosed with breast cancer, she founded the Breast Cancer Research Foundation and co-created the pink ribbon campaign, now a worldwide symbol of breast health. “She was an incredible inspiration to everyone in our industry,” says InStyle Beauty Director Amy Synnott. “Her dedication to breast cancer research raised the bar in terms of what one person—and one cosmetics company—could do to make a difference in the world.” Lauder is survived by her husband, two sons and five grandchildren.