The royal and FLOTUS opened the ceremony to honor the wounded, injured or sick armed services people whom the event was founded for in 2014.
Addressing the crowd of fans and competitors, Prince Harry started proceedings at Walt Disney World's ESPN Wide World of Sports Complex, Fla., saying: "I learned about the importance of teamwork and camaraderie that only military service can teach you," he said. "I joined the army because for a long time I just wanted to be one of the guys."
He also made sure to give credit to service people suffering from non-physical health problems, highlighting: "Let's cheer for the woman who fought through post-traumatic stress and let's celebrate the soldier who was brave enough to get help for his depression... They weren't too tough to admit that they struggled with mental health."
Next, Obama joined him, looking sleek in a tailored black sleeveless jacket belted over matching cigarette pants. She thanked him for his work on the event: "He is truly our Prince Charming, isn't he? He should be proud of himself for his work."
The pair then took front row seats, joining stars like Morgan Freeman, as team captains and competitors appeared on stage and the Games' flag was brought into the stadium by servicemen and women.
The prince's Invictus Games will feature 10 events, including wheelchair basketball and indoor rowing, with 500 competitors from 14 countries.