The couple, who met on the set of Mr. & Mrs. Smith, have been together since 2004 and wed in August 2014 in a romantic ceremony in the south of France.
While they took 10 years to finally walk down the aisle, they wasted no time in expanding their family: Jolie and Pitt are parents to six children, including Maddox, 15; Pax, 12; Zahara, 11; Shiloh, 10; Knox, 8; and Vivienne, 8.
VIDEO: 7 of Brangelina's Cutest Couple Moments Through the Years
Since the inception of "Brangelina," the duo quickly became a force to be reckoned with on the red carpet, making hearts throb around their world with their adorable displays of affection. Who can forget that time Jolie’s right leg won the red carpet at the 2012 Academy Awards with the actress's handsome partner by the her side?
As we mourn the end of their relationship, grab a pint of ice cream and join us in taking a look back at their cutest couple moments through the years.