The 2009 wedding of Izzie Stephens (Katherine Heigl) and Alex Karev (Justin Chambers) on Grey's Anatomy
had us reaching for the tissues! After finding out Izzie had an incurable tumor, Meredith Grey (Ellen Pompeo) gave her wedding ceremony (and dress!) to Izzie. The ornate Kenneth Pool design featured a long tulle skirt with an elaborate crystal-embroidered bodice.
MORE: See Katherine Heigl's Transformation.